PhD position Photopharmacology (1.0 FTE)

Job description

Without biological membranes, there would be no life as we know it. Transport of molecules and information across these membranes is carried out by integral membrane protein channels, receptors, pumps and transporters. Living cells maintain chemical gradients and electrical potential differences across their membranes using proteins that represent the majority of all current drug targets. Therefore, membrane proteins have been the focus of intense efforts to obtain high resolution macromolecular structure information. However, the current lack of experimental methods to carry out time-resolved structural studies of membrane proteins at physiological temperatures and under physiological gradients leaves a gigantic blind spot is our mechanistic understanding.

This project is a part of an ERC-funded consortium that will address this challenge by bringing together complementary expertise in membrane protein biology, time-resolved struct...