Principal Scientist - Lead Discovery and Targeted Protein Degradation Biochemistry

Amgen SA · thousand oaks, ventura county, ca, United-States

Location
thousand oaks
Job Type
Full-time
Posted
July 03, 2026

Job Description

Principal Scientist – Lead Discovery and Targeted Protein Degradation Biochemistry What you will do Let's do this. Let's change the world. In this role, you will lead protein reagent generation and biochemical assay development to support challenging drug discovery campaigns, including induced proximity and targeted protein degradation (TPD) programs. We are seeking an exceptional scientist with deep expertise in protein biochemistry and mechanistic assay development. The successful candidate will lead a small team and provide scientific leadership across drug discovery programs from hit identification through validation and optimization. Within LD-TPD, this role will develop and execute strategies for protein production, biochemical and biophysical assay development, and mechanistic characterization to support the discovery and advancement of novel small‐molecule therapeutics. The successful candidate will: Lead protein expression, purification, and characterization strate...

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